| Quiescent T cells and HIV: an unresolved relationship. | |
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MedLine Citation:
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PMID: 20725862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of HIV to infect quiescent CD4+ T cells has been a topic of intense debate. While early studies suggested that the virus could not infect this particular T cell subset, subsequent studies using more sensitive protocols demonstrated that these cells could inefficiently support HIV infection. Additional studies showed that the kinetics of infection in quiescent cells was delayed and multiple stages of the viral life cycle were marred by inefficiencies. Despite that, proviral DNA has been found in these cells presenting them as a potential viral reservoir. Therefore, a better understanding of the relationship between HIV and quiescent T cells may lead to further advances in the field of HIV. |
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Authors:
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Dimitrios N Vatakis; Christopher C Nixon; Jerome A Zack |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunologic research Volume: 48 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2011-06-14 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 110-21 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Hematology/Oncology, UCLA AIDS Institute, David Geffen School of Medicine at UCLA, 615 Charles E. Young Drive South, Los Angeles, CA 90095, USA. dvatakis@ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes
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physiology*,
virology Cell Cycle / genetics, immunology Disease Reservoirs / virology* Gene Expression Regulation, Viral HIV / pathogenicity, physiology* HIV Infections / immunology*, virology Host-Pathogen Interactions Humans T-Lymphocyte Subsets / physiology*, virology Virulence / genetics, immunology Virus Latency / genetics, immunology Virus Replication / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI070010/AI/NIAID NIH HHS; AI28697/AI/NIAID NIH HHS; P30 AI028697/AI/NIAID NIH HHS; R01 AI070010/AI/NIAID NIH HHS |
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