Document Detail

Quick stretch increases the production of inositol 1,4,5-trisphosphate (IP3) in porcine coronary artery.
MedLine Citation:
PMID:  7911965     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to know whether the formation of inositol 1,4,5-trisphosphate (IP3) is increased by quick stretch, a dynamic mechanical stimulus in porcine coronary artery in order to inquiry the possibility that IP3 could mediate Ca2+ release in the stretch-induced contraction. Quick stretching of a helical strip of porcine coronary artery at a rate of 10 cm/sec, the amount of stretch equivalent to 140% of the initial muscle length (= 100%), and the stimulus period of 30 sec with 20-min intervals, produced delayed contraction. Quick stretching increased the content of IP3 about three-fold over the control basal level, which always preceded the contraction. A putative phospholipase C inhibitor, 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC), abolished the increase in the formation of IP3 and partially inhibited the stretch-induced contraction. The results suggest that quick stretching increases the formation of IP3 through a possible mechanism for activation of phospholipase C, which may lead to release of Ca2+ into myoplasm and to further activation of the contractile elements.
Y Tanaka; S Hata; H Ishiro; K Ishii; K Nakayama
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  55     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1994  
Date Detail:
Created Date:  1994-07-19     Completed Date:  1994-07-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  227-35     Citation Subset:  IM    
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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MeSH Terms
Acetylcholine / pharmacology
Adrenergic beta-Antagonists / pharmacology
Atropine / pharmacology
Carbamates / pharmacology
Coronary Vessels / metabolism*,  physiology
Inositol 1,4,5-Trisphosphate / metabolism*
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / physiology*
Nicardipine / pharmacology
Type C Phospholipases / antagonists & inhibitors
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbamates; 0/Phenylcarbamates; 10556-88-4/2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate; 51-55-8/Atropine; 51-84-3/Acetylcholine; 55985-32-5/Nicardipine; 85166-31-0/Inositol 1,4,5-Trisphosphate; EC 3.1.4.-/Type C Phospholipases

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