| Quetiapine therapy for posttraumatic stress disorder. | |
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MedLine Citation:
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PMID: 12452747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of improvement in posttraumatic stress disorder (PTSD) after adjunctive therapy with quetiapine. CASE SUMMARY: A 49-year-old white man witnessed a traumatic event and experienced severe PTSD. He was started on paroxetine, with increases in dosage and no significant improvement. Quetiapine was added to his regimen, with increased doses resulting in improvement of PTSD symptoms, both clinically and as measured on the Hamilton-D rating scale for depression and the clinician-administered PTSD screen. DISCUSSION: This is the first case published in the English language literature describing improvement in PTSD symptoms after treatment with quetiapine. There are several treatment options for PTSD, but some severe cases may require treatment with antipsychotic medications. Because of the lower risks of serious adverse effects, the newer atypical antipsychotics are much safer than the older antipsychotics. Although use of risperidone and olanzapine in the successful treatment of PTSD has been reported in the literature, there are no reports of quetiapine use in this clinical condition. CONCLUSIONS: Quetiapine appeared to improve clinical signs and symptoms of PTSD in this patient. It may be a treatment option in other severe cases of PTSD. |
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Authors:
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S Pirzada Sattar; Bernadette Ucci; Kathleen Grant; Subhash C Bhatia; Frederick Petty |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 36 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-05-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 1875-8 Citation Subset: IM |
Affiliation:
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School of Medicine, Creighton University, Omaha, NE, USA. syed.sattar@med.va.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism Antipsychotic Agents / therapeutic use* Dibenzothiazepines / therapeutic use* Humans Male Middle Aged Stress Disorders, Post-Traumatic / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/quetiapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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