Document Detail


Quetiapine induced hypomania: a case report and a review of the literature.
MedLine Citation:
PMID:  22950378     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: The 5-HT2 antagonistic action of quetiapine may disinhibit the dopaminergic system enhancing dopaminergic activity in the forebrain and influencing the mood state. Our objective is to investigate the possible induction of manic symptoms by quetiapine through a case report and a review of the literature.Method: We report the case of a 54 year old woman suffering from bipolar depression who developed hypomania seven weeks after the initiation of 300 mg/d of quetiapine. A literature review concerning the induction of hypomania or mania by quetiapine have retrieved the presence of seven similar case reports or series.Results: Available literature points toward an early induction of hypomania or mania with low dosage of quetiapine treatment (between 100 and 400 mg/day never exceeding 600 mg/day). Hypomania or mania are possible short term complications that can be present few days to few weeks of treatment initiation. The discontinuation of the drug or the increase of its dose seems to reverse the hypomanic or manic symptoms. Patients described in the literature suffer mostly from schizophrenia.Conclusion: The atypical antipsychotic drug quetiapine, which have antidepressant properties at low doses via its indirect dopamine enhancing activity due its serotoninergic antagonism, appears to be involved in the induction of rare hypomanic or manic state in patients suffering from bipolar disorders and to have mood stabilizing properties at higher doses when its dopamine antagonist activity becomes more prominent. Its manic/hypomanic induction properties should not prevent its administration to patients suffering from bipolar disorder.
Authors:
R Bou Khalil; C Baddoura
Related Documents :
12014768 - Melioidosis of the head and neck.
2071398 - Short-lasting unilateral neuralgiform headache attacks with conjunctival injection, tea...
18209128 - Perioral burns after adenotonsillectomy: a potentially serious complication.
2001158 - Tumefactive fibroinflammatory lesion of the extremity. report of a case and review of t...
11054038 - Carcinosarcoma in a bladder diverticulum. a case report and literature review.
9008038 - Contralateral testicular torsion after previous unilateral orchiopexy for undescended t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-30
Journal Detail:
Title:  Current drug safety     Volume:  -     ISSN:  2212-3911     ISO Abbreviation:  Curr Drug Saf     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101270895     Medline TA:  Curr Drug Saf     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Cross Psychiatric Hospital, Jalledib, Lebanon. Saint Joseph University, Beirut, Lebanon. ramiboukhalil@hotmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In Silico Prediction of Adverse Drug Reactions and Toxicities Based on Structural, Biological and Cl...
Next Document:  Specific TNF-Alpha Inhibition in Aneurysm Formation and Subarachnoid Hemorrhage.