| Quetiapine and citalopram: aetiological significances in serotonin syndrome. | |
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MedLine Citation:
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PMID: 16862204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of atypical antipsychotic medication is increasing, with an increase in reported side-effects. The first reported case of quetiapine and citalopram-associated serotonin syndrome is discussed with reference to a Medline, Embase, and PsycINFO literature search. The putative aetiological mechanism is supersensitivity of 5-HT(1A) receptors (quetiapine) within an environment of increased synaptic available serotonin (citalopram). The symptom profile of serotonin syndrome overlaps with neuroleptic malignant syndrome, but can be reliably differentiated using a time and toxicity scale. |
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Authors:
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Karl Marlowe; Dorothea Schirgel |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-07-07 |
Journal Detail:
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Title: The New Zealand medical journal Volume: 119 ISSN: 1175-8716 ISO Abbreviation: N. Z. Med. J. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-24 Completed Date: 2006-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401067 Medline TA: N Z Med J Country: New Zealand |
Other Details:
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Languages: eng Pagination: U2058 Citation Subset: IM |
Affiliation:
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Tower Hamlets Early Intervention Service, Royal London Hospital, St Clement's, 2A Bow Road, Mile End, London E3 4LL, UK. karl.marlowe@elcmht.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alprazolam / therapeutic use Anti-Anxiety Agents / therapeutic use Antipsychotic Agents / adverse effects* Bipolar Disorder / drug therapy* Citalopram / adverse effects* Dibenzothiazepines / adverse effects* Drug Therapy, Combination Female Humans Risperidone / therapeutic use Serotonin Antagonists / therapeutic use Serotonin Syndrome / chemically induced*, drug therapy Serotonin Uptake Inhibitors / adverse effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/Serotonin Antagonists; 0/Serotonin Uptake Inhibitors; 0/quetiapine; 106266-06-2/Risperidone; 28981-97-7/Alprazolam; 59729-33-8/Citalopram |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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