Document Detail


Quetiapine and breast feeding.
MedLine Citation:
PMID:  17374621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To quantify the relative infant dose of quetiapine during breast feeding, describe the milk:plasma (M:P) ratio, and determine the well-being of the exposed infant. CASE SUMMARY: A 26-year-old mother and her 3-month-old son were studied over a 24 hour quetiapine dose interval at steady-state. Quetiapine concentrations were quantified by high-performance liquid chromatography. Infant exposure was calculated as the concentration in milk multiplied by an estimated milk production of 0.15 L/kg/day and normalized to the weight-adjusted maternal dose. The average concentration in milk was 41 microg/L, the M:P ratio (measured using average concentrations in the elimination phase) was 0.29, and the relative infant dose was 0.09% of the maternal weight-adjusted dose (7273 microg/kg/day). The infant plasma concentration of 1.4 microg/L was some 6% of the corresponding maternal plasma concentration. No adverse effects were noted in the infant. DISCUSSION: Our findings of an infant exposure to quetiapine of less than 0.1% of the maternal dose and a lack of adverse effects confirm and extend the findings of 2 previous studies. CONCLUSIONS: Although limited, the data shown here support the prescription of quetiapine to a breast-feeding mother following a careful individual risk/benefit analysis. We suggest regular monitoring of infant progress and occasional measurement of quetiapine in the infant's plasma.
Authors:
Jonathan Rampono; Judith H Kristensen; Kenneth F Ilett; L Peter Hackett; Rolland Kohan
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-20
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  41     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  711-4     Citation Subset:  IM    
Affiliation:
Department of Psychological Medicine, King Edward Memorial Hospital for Women, Subiaco, Western Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / adverse effects,  analysis,  blood*
Breast Feeding*
Chromatography, High Pressure Liquid
Dibenzothiazepines / adverse effects,  analysis,  blood*
Female
Humans
Infant
Male
Milk, Human / chemistry
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/quetiapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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