Document Detail

Question 6: coevolution theory of the genetic code: a proven theory.
MedLine Citation:
PMID:  17611816     Owner:  NLM     Status:  MEDLINE    
The coevolution theory proposes that primordial proteins consisted only of those amino acids readily obtainable from the prebiotic environment, representing about half the twenty encoded amino acids of today, and the missing amino acids entered the system as the code expanded along with pathways of amino acid biosynthesis. The isolation of genetic code mutants, and the antiquity of pretran synthesis revealed by the comparative genomics of tRNAs and aminoacyl-tRNA synthetases, have combined to provide a rigorous proof of the four fundamental tenets of the theory, thus solving the riddle of the structure of the universal genetic code.
Jeffrey Tze-Fei Wong
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Publication Detail:
Type:  Journal Article     Date:  2007-07-05
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  37     ISSN:  0169-6149     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  403-8     Citation Subset:  IM; S    
Department of Biochemistry and Applied Genomics Laboratory, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
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MeSH Terms
Amino Acids / biosynthesis,  chemistry,  genetics
Evolution, Chemical*
Genetic Code*
Models, Theoretical*
Proteins / chemistry,  genetics,  metabolism
RNA, Transfer / genetics,  metabolism
Reg. No./Substance:
0/Amino Acids; 0/Codon; 0/Proteins; 9014-25-9/RNA, Transfer

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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