Document Detail


Questing for circadian dependence in ST-segment-elevation acute myocardial infarction: a multicentric and multiethnic study.
MedLine Citation:
PMID:  23661713     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Four monocentric studies reported that circadian rhythms can affect left ventricular infarct size after ST-segment-elevation acute myocardial infarction (STEMI).
OBJECTIVE: To further validate the circadian dependence of infarct size after STEMI in a multicentric and multiethnic population.
METHODS AND RESULTS: We analyzed a prospective cohort of subjects with first STEMI from the First Acute Myocardial Infarction study that enrolled 1099 patients (ischemic time <6 hours) in Italy, Scotland, and China. We confirmed a circadian variation of STEMI incidence with an increased morning incidence (from 6:00 am till noon). We investigated the presence of circadian dependence of infarct size plotting the peak creatine kinase against time onset of ischemia. In addition, we studied the patients from the 3 countries separately, including 624 Italians; all patients were treated with percutaneous coronary intervention. We adopted several levels of analysis with different inclusion criteria consistent with previous studies. In all the analyses, we did not find a clear-cut circadian dependence of infarct size after STEMI.
CONCLUSIONS: Although the circadian dependence of infarct size supported by previous studies poses an intriguing hypothesis, we were unable to converge toward their conclusions in a multicentric and multiethnic setting. Parameters that vary as a function of latitude could potentially obscure the circadian variations observed in monocentric studies. We believe that, to assess whether circadian rhythms can affect the infarct size, future study design should not only include larger samples but also aim to untangle the molecular time-dynamic mechanisms underlying such a relation.
Authors:
Enrico Ammirati; Nicole Cristell; Domenico Cianflone; Anna-Chiara Vermi; Giancarlo Marenzi; Monica De Metrio; Neal G Uren; Dayi Hu; Timothy Ravasi; Attilio Maseri; Carlo V Cannistraci
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Circulation research     Volume:  112     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-10     Completed Date:  2013-07-09     Revised Date:  2013-09-23    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e110-4     Citation Subset:  -    
Affiliation:
San Raffaele Scientific Institute and Vita-Salute University, Milan, Italy. ammirati.enrico@hsr.it
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Comment On:
Circ Res. 2012 Jan 6;110(1):105-10   [PMID:  22095727 ]
Comment In:
Circ Res. 2013 Aug 2;113(4):e42   [PMID:  23908335 ]
Circ Res. 2013 May 10;112(10):e115-7   [PMID:  23661714 ]

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