Document Detail

Quercetin and endurance exercise capacity: a systematic review and meta-analysis.
MedLine Citation:
PMID:  21606866     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The study's purpose was to perform a systematic review of the literature and meta-analysis to examine whether quercetin ingestion increases endurance exercise capacity.
METHODS: A search of the literature was conducted using the key words quercetin, performance, exercise, endurance, and aerobic capacity. Eleven studies were identified as meeting the inclusion criteria providing data on 254 human subjects. Across all studies, subject presupplementation VO(2max) ranged from 41 to 64 mL·kg(-1)·min(-1) (median = 46), and median treatment duration was 11 d with a median dosage of 1000 mg·d(-1). Effect sizes (ES) were calculated as the standardized mean difference, and meta-analyses were completed using a random-effects model.
RESULTS: The ES calculated for all studies combining VO(2max) and endurance performance measures indicates a significant effect favoring quercetin over placebo (ES = 0.15, P = 0.021, 95% confidence interval = 0.02-0.27), but the magnitude of effect is considered between trivial and small, equating to a ∼2% [corrected] improvement of quercetin over placebo. Using a subgroup meta-analysis comparing quercetin's effect on endurance exercise performance versus VO(2max), no significant difference was found (P = 0.69). Meta-regression of study ES relative to subjects' fitness level or plasma quercetin concentration achieved by supplementation was also not significant.
CONCLUSIONS: On average, quercetin provides a statistically significant benefit in human endurance exercise capacity (VO(2max) and endurance exercise performance), but the effect is between trivial and small. Experimental factors that explain the between-study variation remain to be elucidated.
Jochen Kressler; Melinda Millard-Stafford; Gordon L Warren
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-18     Completed Date:  2012-03-30     Revised Date:  2012-04-12    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2396-404     Citation Subset:  IM; S    
School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA 30332-0356, USA.
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MeSH Terms
Athletic Performance / physiology
Dietary Supplements*
Exercise / physiology*
Oxygen Consumption / drug effects,  physiology
Physical Endurance / drug effects*
Quercetin / administration & dosage*,  blood
Reg. No./Substance:
Comment In:
Med Sci Sports Exerc. 2012 Mar;44(3):556; author reply 557   [PMID:  22343561 ]
Erratum In:
Med Sci Sports Exerc. 2012 Mar;44(3):558-9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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