Document Detail


Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
MedLine Citation:
PMID:  18692520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.
Authors:
Nadine Saul; Kerstin Pietsch; Ralph Menzel; Christian E W Steinberg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-07-23
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  129     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2009-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  611-3     Citation Subset:  IM    
Affiliation:
Humboldt-Universität zu Berlin, Department of Biology, Arboretum, Spaethstr. 80/81, 12437 Berlin, Germany. nadines1976@aol.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics*,  physiology*
Dose-Response Relationship, Drug
Gene Expression Profiling
Longevity / drug effects,  genetics*
Mutation*
Oxidative Stress
Quercetin / pharmacology*
Temperature
Time Factors
Transcription Factors / genetics*,  physiology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Caenorhabditis elegans Proteins; 0/Transcription Factors; 0/daf-16 protein, C elegans; 117-39-5/Quercetin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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