Document Detail

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice.
MedLine Citation:
PMID:  23359794     Owner:  NLM     Status:  MEDLINE    
Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and (1)H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p<0.001) and total poly unsaturated fatty acids (PUFA) were increased with 13% (p<0.01). Palmitic acid, oleic acid, and linoleic acid were all decreased by 9-15% (p<0.05) in quercetin-fed mice. Both palmitic acid and oleic acid can be oxidized by omega (ω)-oxidation. Gene expression profiling showed that quercetin increased hepatic lipid metabolism, especially ω-oxidation. At the gene level, this was reflected by the up-regulation of cytochrome P450 (Cyp) 4a10, Cyp4a14, Cyp4a31 and Acyl-CoA thioesterase 3 (Acot3). Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s) and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3) were also up-regulated in the quercetin-fed mice. We conclude that quercetin intake increased hepatic lipid ω-oxidation and lowered corresponding circulating lipid levels, which may contribute to potential beneficial effects on CVD.
Elise F Hoek-van den Hil; Jaap Keijer; Annelies Bunschoten; Jacques J M Vervoort; Barbora Stankova; Melissa Bekkenkamp; Laure Herreman; Dini Venema; Peter C H Hollman; Eva Tvrzicka; Ivonne M C M Rietjens; Evert M van Schothorst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-24
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-09-06     Revised Date:  2014-10-22    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e51588     Citation Subset:  IM    
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MeSH Terms
Chromatography, Gas
Chromatography, High Pressure Liquid
Fatty Acids, Unsaturated / metabolism
Lipid Metabolism
Lipids / blood*
Liver / drug effects*,  metabolism
Magnetic Resonance Spectroscopy
Mice, Inbred C57BL
Quercetin / pharmacology*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Lipids; 9IKM0I5T1E/Quercetin
Erratum In:
PLoS One. 2013;8(9). doi:.1371/annotation/53e96376-38fe-40e7-b73a-60e7232cef0e

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