| Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice. | |
| | |
MedLine Citation:
|
PMID: 23359794 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and (1)H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p<0.001) and total poly unsaturated fatty acids (PUFA) were increased with 13% (p<0.01). Palmitic acid, oleic acid, and linoleic acid were all decreased by 9-15% (p<0.05) in quercetin-fed mice. Both palmitic acid and oleic acid can be oxidized by omega (ω)-oxidation. Gene expression profiling showed that quercetin increased hepatic lipid metabolism, especially ω-oxidation. At the gene level, this was reflected by the up-regulation of cytochrome P450 (Cyp) 4a10, Cyp4a14, Cyp4a31 and Acyl-CoA thioesterase 3 (Acot3). Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s) and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3) were also up-regulated in the quercetin-fed mice. We conclude that quercetin intake increased hepatic lipid ω-oxidation and lowered corresponding circulating lipid levels, which may contribute to potential beneficial effects on CVD. |
| | |
Authors:
|
Elise F Hoek-van den Hil; Jaap Keijer; Annelies Bunschoten; Jacques J M Vervoort; Barbora Stankova; Melissa Bekkenkamp; Laure Herreman; Dini Venema; Peter C H Hollman; Eva Tvrzicka; Ivonne M C M Rietjens; Evert M van Schothorst |
Related Documents
:
|
18557824 - Effects of abiotic stressors on synthesis of the mycosporine-like amino acid shinorine ... 16937334 - Bile acid salt binding with colesevelam hcl is not affected by suspension in common bev... 23166034 - Dna microarray analysis identified molecular pathways mediating the effects of suppleme... 994314 - The long-term hemodynamic effect of fusaric acid in elderly hypertensive patients. 9266824 - Resolution of the phytanic acid alpha-oxidation pathway: identification of pristanal as... 7879704 - Immune-related edemagenic activity of glutamines and glutamic acid, components of immun... |
Publication Detail:
|
Type: Journal Article Date: 2013-01-24 |
Journal Detail:
|
Title: PloS one Volume: 8 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2013 |
Date Detail:
|
Created Date: 2013-01-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
|
Languages: eng Pagination: e51588 Citation Subset: IM |
Affiliation:
|
Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands ; Division of Toxicology, Wageningen University, Wageningen, The Netherlands ; RIKILT-Institute of Food Safety, Wageningen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An accurate method for the qualitative detection and quantification of mycobacterial promoter activi...
Next Document: Fluorescence In Situ Hybridization and Immunohistochemistry as Diagnostic Methods for ALK Positive N...