| Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells. | |
| | |
MedLine Citation:
|
PMID: 21173056 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Quercetin is one of the naturally occurring dietary flavonol compounds. It is present abundantly in plants and has chemopreventive and anticancer effects. To investigate its anticancer mechanism, we examined the activity of quercetin against acute leukemia cell line, HL-60. Our results showed that quercetin inhibited cell proliferation and induced apoptosis in a time- and dose-dependent manner. Furthermore, quercetin down-regulated the expression of anti-apoptosis protein Bcl-2 and up-regulated the expression of pro-apoptosis protein Bax. Caspase-3 was also activated by quercetin, which started a caspase-3-depended mitochodrial pathway to induce apoptosis. It was also found that quercetin inhibited the expression of the cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein. Taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting Cox-2 expression and regulates the expression of downstream apoptotic components, including Bcl-2 and Bax. Quercetin can be a potent and promising medicine which might be safely used in leukemia therapy. |
| | |
Authors:
|
Guomin Niu; Songmei Yin; Shuangfeng Xie; Yiqing Li; Danian Nie; Liping Ma; Xiuju Wang; Yudan Wu |
Related Documents
:
|
9917496 - Induction of differentiation and apoptosis in the prostate cancer cell line lncap by so... 19435426 - Involvement of high mobility group b proteins in cisplatin-induced cytotoxicity in squa... 12538846 - Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-medi... 18809656 - A combination of proteasome inhibitors and antibiotics prevents lethality in a septic s... 22456466 - Inflammatory regulators of redirected neural migration in the injured brain. 17660506 - Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta biochimica et biophysica Sinica Volume: 43 ISSN: 1745-7270 ISO Abbreviation: Acta Biochim. Biophys. Sin. (Shanghai) Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101206716 Medline TA: Acta Biochim Biophys Sin (Shanghai) Country: China |
Other Details:
|
Languages: eng Pagination: 30-7 Citation Subset: IM |
Affiliation:
|
Department of Hematology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou 510120, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of antibiotic marker-free creeping bentgrass resistance against herbicides.
Next Document: Poliovirus 2Apro induces the nucleic translocation of poliovirus 3CD and 3C' proteins.