Document Detail

Quercetin does not alter lipopolysaccharide-induced fever in rats.
MedLine Citation:
PMID:  18284816     Owner:  NLM     Status:  MEDLINE    
Fever is considered an important component of the acute phase response of the body in defence against invading organisms such as bacteria. Quercetin, an important representative of the flavonoid class, has been extensively studied as an anti-inflammatory agent. In the present study, we investigated the effect of quercetin, administered orally (5, 25 and 50 mg kg(-1)) or intraperitoneally (50 mg kg(-1)), on the febrile response induced by either intraperitoneally (50 mug kg(-1)) or intravenously (5 mug kg(-1)) injected lipopolysaccharide (LPS from Escherichia coli) in rats. In contrast with the well known anti-inflammatory activity of quercetin, the results demonstrate that quercetin, at the doses used, did not alter the fever induced by LPS, regardless of the route of administration.
Alexandre Kanashiro; Renes R Machado; David do C Malvar; Fernando A Aguiar; Glória E P Souza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  60     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
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MeSH Terms
Administration, Oral
Anti-Inflammatory Agents / administration & dosage,  pharmacology*
Antioxidants / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Fever / chemically induced,  drug therapy*
Injections, Intraperitoneal
Injections, Intravenous
Lipopolysaccharides / toxicity
Quercetin / administration & dosage,  pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Lipopolysaccharides; 117-39-5/Quercetin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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