Document Detail

Quercetin is bioavailable from a single ingestion of grape juice.
MedLine Citation:
PMID:  17135030     Owner:  NLM     Status:  MEDLINE    
The in vivo bioactivity of polyphenols will depend on their bioavailability. Grape juice is an important source of dietary phenolics. This paper reports results that prove that quercetin (3,3',4',5,7-pentahydroxyflavone) is bioavailable after a single ingestion of red grape juice by healthy volunteers. Blood plasma samples were collected before and after 2 h of ingestion of 100 ml of concentrated grape juice (n = 14), and of a placebo solution (n =6). Significant differences in the variation of the total plasma quercetin content (before and after ingestion) between the grape juice ingestion group (3.1 microg/l increase, as a mean) and the placebo group (6.0 microg/l decrease, as a mean) were found. This relatively low increase in comparison with that obtained after 2 h of ingestion of onions (201 microg/l, as a mean) and with those reported in the literature for other foods/beverages was attributed to differences in the amount of quercetin ingested, in the form in which quercetin is present, and in the food matrix.
Alberto Dávalos; Patricia Castilla; Carmen Gómez-Cordovés; Begoña Bartolomé
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of food sciences and nutrition     Volume:  57     ISSN:  0963-7486     ISO Abbreviation:  Int J Food Sci Nutr     Publication Date:    2006 Aug-Sep
Date Detail:
Created Date:  2006-11-30     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432922     Medline TA:  Int J Food Sci Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM    
Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain.
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MeSH Terms
Biological Availability
Nutritive Value
Onions / chemistry
Quercetin / analysis,  blood,  pharmacokinetics*
Vitis / chemistry,  metabolism*
Reg. No./Substance:

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