Document Detail


Quercetin, Siamois 1 and Siamois 2 induce apoptosis in human breast cancer MDA-mB-435 cells xenograft in vivo.
MedLine Citation:
PMID:  17172819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to investigate the apoptosis-inducing activities of quercetin, Siamois 1, and Siamois 2 against invasive estrogen-receptor negative MDA-MB 435 cells xenografted in athymic nude mice. This study clearly demonstrated that these compounds exhibited apoptosis-inducing activities in cell culture system. Quercetin (20 microg/mL), Siamois 1 (100 microg/mL), and Siamois 2 (200 microg/mL) can induce apoptotic cell death by 40 +/-5%, 44 +/- 14 %, and 31 +/- 13 %, respectively. Two-fold of IC50 of these compounds were clearly found to induce apoptosis in breast tumor tissue which can be determined by 99mTc-Annexin V scintigraphy and histological staining. This is the first report that the apoptosis-inducing effects of quercetin, Siamois 1 and Siamois 2 on the MDA-MB 435 cell in vitro were effectively extrapolated to the in vivo situation. These compounds might be considered as a simple dietary supplement and with further clinical investigation for their use as a nutrition-based intervention in breast cancer treatment.
Authors:
Samarn Dechsupa; Suchart Kothan; Jackie Vergote; Gerard Leger; Antoine Martineau; Simone Berangeo; Rachain Kosanlavit; Jean-Luc Moretti; Samlee Mankhetkorn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer biology & therapy     Volume:  6     ISSN:  1538-4047     ISO Abbreviation:  Cancer Biol. Ther.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137842     Medline TA:  Cancer Biol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-61     Citation Subset:  IM    
Affiliation:
Laboratory of Physical Chemistry, Molecular and Cellular Biology, Center of Excellence for Molecular Imaging, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiong Mai University, Chiong Mai, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Breast Neoplasms / pathology*
Cell Proliferation / drug effects
Humans
Inhibitory Concentration 50
Mice
Mice, Nude
Quercetin / analogs & derivatives*,  pharmacology*
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Siamois 1; 0/Siamois 2; 117-39-5/Quercetin
Comments/Corrections
Comment In:
Cancer Biol Ther. 2007 Jan;6(1):62-3   [PMID:  17224638 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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