| Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production. | |
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MedLine Citation:
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PMID: 19899776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quercetin (1) is known to have both antioxidant and antinociceptive effects. However, the mechanism involved in its antinociceptive effect is not fully elucidated. Cytokines and reactive oxygen species have been implicated in the cascade of events resulting in inflammatory pain. Therefore, we evaluated the antinociceptive mechanism of 1 focusing on the role of cytokines and oxidative stress. Intraperitoneal and oral treatments with 1 dose-dependently inhibited inflammatory nociception induced by acetic acid and phenyl-p-benzoquinone and also the second phase of formalin- and carrageenin-induced mechanical hypernociception. Compound 1 also inhibited the hypernociception induced by cytokines (e.g., TNFalpha and CXCL1), but not by inflammatory mediators that directly sensitize the nociceptor such as PGE2 and dopamine. On the other hand, 1 reduced carrageenin-induced IL-1beta production as well as carrageenin-induced decrease of reduced glutathione (GSH) levels. These results suggest that 1 exerts its analgesic effect by inhibiting pro-nociceptive cytokine production and the oxidative imbalance mediation of inflammatory pain. |
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Authors:
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Daniel A Val?rio; Sandra R Georgetti; Danilo A Magro; Rubia Casagrande; Thiago M Cunha; Fabiana T M C Vicentini; Silvio M Vieira; Maria J V Fonseca; Sergio H Ferreira; Fernando Q Cunha; Waldiceu A Verri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2009-12-16 Revised Date: 2010-05-27 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1975-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, S?o Paulo 14049-900, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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chemistry,
pharmacology* Antioxidants / chemistry, pharmacology* Biological Products / chemistry, pharmacology* Cytokines / drug effects*, metabolism Inflammation / physiopathology* Molecular Structure Oxidative Stress* Pain / drug therapy* Quercetin / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Antioxidants; 0/Biological Products; 0/Cytokines; 117-39-5/Quercetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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