Document Detail

Quercetin Does Not Attenuate Changes in Markers of Muscle Function or Inflammation after Eccentric Exercise.
MedLine Citation:
PMID:  22805422     Owner:  NLM     Status:  Publisher    
The flavonoid quercetin is purported to have potent antioxidant/anti-inflammatory properties. This study examined if quercetin supplementation attenuates indicators of exercise-induced muscle damage in a double-blind laboratory study. Thirty healthy subjects were randomized to quercetin (QU) or placebo (PL) supplementation and performed two separate sessions of 24 eccentric contractions of the elbow flexors. Muscle strength, soreness, resting arm angle, upper-arm swelling, serum creatine kinase activity (CK), plasma quercetin (PQ), interleukin-6 (IL-6), and c-reactive protein (CRP) were assessed before and for 5 days (d) post-exercise. Subjects then ingested nutrition bars containing 1,000 mg/d QU or PL for 7 d prior to and 5 d following the second exercise session, using the opposite arm. PQ reached 202 ± 52 ng/ml after 7 d supplementation and remained elevated during the 5 d post-exercise recovery period (p < 0.05). Subjects experienced strength-loss (peak = 47%), muscle soreness (peak = 39 ± 6 mm), reduced arm angle (-7 ± 1 deg), CK elevations (peak = 3,307 ± 1,481 U/L), and arm swelling (peak = 11 ± 2 mm) (p < 0.0001), indicating muscle damage and inflammation; however, differences between treatments were not detected. Eccentric-exercise did not alter plasma IL-6 (peak = 1.9 pg/ml) or CRP (peak = 1.6 mg/l), relative to baseline or by treatment. QU supplementation had no effect on markers of muscle damage or inflammation following eccentric exercise of the elbow flexors.
Kevin S O'Fallon; Diksha Kaushik; Bozena Michniak-Kohn; C Patrick Dunne; Edward J Zambraski; Priscilla M Clarkson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-4
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Kinesiology, University of Massachusetts, Amherst, MA.
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