Document Detail

Quenching: fact or fiction?
MedLine Citation:
PMID:  11016664     Owner:  NLM     Status:  MEDLINE    
Fragrance chemicals are a frequently reported cause of allergic contact dermatitis (ACD), a matter which has recently come into considerable prominence, to the point that legislation in Europe is under serious consideration. Certain skin-sensitizing fragrance chemicals have been reported by the producing industry to be rendered safe (quenched), at least in terms of ACD, when they are used in the presence of a specific quenching agent. Accordingly, it seemed timely to review this apparent quenching phenomenon, considering the available data and potential mechanistic hypotheses that might be used to explain it. If it is correct, it should be a phenomenon of potentially enormous value in the elimination of the allergenic properties of at least a proportion of common skin sensitizers. Whilst there is some evidence in man for the occurrence of quenching during the induction of skin sensitization, a much more substantial body of work has failed to find supportive evidence in various animals models, at a chemical level or at elicitation in human subjects with existing allergy. On balance, it is concluded that quenching of fragrance allergens is a phenomenon still awaiting positive evidence of existence.
D Basketter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Contact dermatitis     Volume:  43     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-16     Completed Date:  2001-01-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
SEAC Toxicology Unit, Unilever Research Colworth, Sharnbrook, Bedford, UK.
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MeSH Terms
Chemical Industry
Dermatitis, Allergic Contact / etiology*,  prevention & control*
Immunization / methods*
Perfume / adverse effects*,  chemistry*
Sensitivity and Specificity
Skin Tests
Reg. No./Substance:

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