| The Queensland Lung Cancer Screening Study - Rationale, Design and Methods. | |
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MedLine Citation:
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PMID: 22471951 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Lung cancer is the leading cause of cancer related mortality in Australia. Screening using low-dose computed tomography (LDCT) can reduce lung cancer mortality. The feasibility of screening in Australia is unknown. This paper describes the rationale, design and methods of The Queensland Lung Cancer Screening Study. Aims: To describe the methodology for a feasibility study of lung cancer screening by low-dose computed tomography in Australia. Methods: The Queensland Lung Cancer Screening Study is an on-going, prospective observational study of screening by low-dose computed tomography at a single tertiary institution. Healthy volunteers at high risk of lung cancer (age 60-74 years; smoking history ≥30 pack-years, current or quit within 15 years; FEV1 ≥50% predicted) are recruited from the general public through newspaper advertisement and press release. Participants receive a low-dose computed tomography scan of the chest at baseline, year 1 and year 2 using a multi-detector helical CT and are followed up for a total of five years. Feasibility of screening will be assessed by cancer detection rates, lung nodule prevalence, optimal management strategies for lung nodules, economic costs, healthcare utilization and participant quality of life. Conclusions: Studying LDCT screening in the Australian setting will help us understand how differences in populations, background diseases and healthcare structures modulate screening effectiveness. This information, together with results from overseas randomised studies, will inform and facilitate local policymaking. |
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Authors:
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Rayleen V Bowman; Jane Crossin; Deborah Courtney; Kwun M Fong; Melanie Fuentes; Terence J Hayes; Benjamin J Keir; Henry M Marshall; Elizabeth McCaul; Linda Passmore; Stanley Redmond; Richard E Slaughter; Ian Smith; Ian A Yang; Morgan Windsor; Paul V Zimmerman |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-4 |
Journal Detail:
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Title: Internal medicine journal Volume: - ISSN: 1445-5994 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092952 Medline TA: Intern Med J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Internal Medicine Journal © 2012 Royal Australasian College of Physicians. |
Affiliation:
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Department of Thoracic Medicine Medical Imaging, The Prince Charles Hospital, Rode Road, CHERMSIDE QLD Australia 4032 Biomedical Technology Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland Australia St Andrew's War Memorial Hospital, GPO Box 764, Brisbane, Queensland, Australia. |
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