Document Detail

Quaternized chitosan (QCS) nanoparticles as a novel delivery system for ammonium glycyrrhizinate.
MedLine Citation:
PMID:  21137945     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The aim of this study was to generate a new type of nanoparticles made of quaternized chitosan (QCS) and poly(aspartic acid) via the ionotropic gelation technique and to evaluate their potential for the association and delivery of ammonium glycyrrhizinate (GLA). The effects of the pH value of nanoparticles, QCS molecular weight (Mw) and poly(aspartic acid) concentration on GLA encapsulation were studied. Suitably pH value of nanoparticles, moderate QCS MW, optimal concentration ratio of poly(aspartic acid) and QCS favored higher GLA encapsulation efficiency. The release of GLA from nanoparticles was pH-dependent. Fast release occurred in 0.1 M phosphate buffer solution (PBS, pH = 7.4), while the release was slow in 0.1 M HCl (pH = 1.2). The results showed that the new QCS/poly(aspartic acid) nanoparticles have a promising potential in GLA delivery system.
Tie wei Wang; Qing Xu; Yan Wu; Ai jun Zeng; Mingjun Li; Hongxia Gao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  10     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7402-5     Citation Subset:  -    
National Center for Nanoscience and Technology, China, Beijing 100190, China.
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