| Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV. | |
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MedLine Citation:
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PMID: 11807974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chelerythrine, sanguinarine and an alkaloid extract from Macleaya cordata--sanguiritrin--were found to be inhibitors of aminopeptidase A and dipeptidyl peptidase IV, while fagaronine inhibited dipeptidyl peptidase IV only. At 50 microM, chelerythrine, sanguinarine and sanguiritrin inhibited aminopeptidase N by 82%, 82%, 88%, DPP IV by 38%, 62%, 57%, and fagaronine by 34%, respectively. When bovine serum albumin (500 microg/mL) was added, the inhibition of both proteases by quaternary benzo[c]phenanthridine alkaloids (QBA) (50 microM) was significantly diminished. Strong interaction of chelerythrine and sanguinarine with bovine and human serum albumin was proved by electrophoretic determination of their respective conditional binding constants. |
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Authors:
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Aleksi Sedo; Kvetoslava Vlasicová; Petr Barták; Radim Vespalec; Jaroslav Vicar; Vilim Simánek; Jitka Ulrichová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 16 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-24 Completed Date: 2002-05-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 84-7 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Ltd. |
Affiliation:
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Joint Laboratory of Cancer Cell Biology of the 1st Faculty of Medicine, Charles University and Institute of Physiology, Academy of Sciences, 121 08 Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaloids
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chemistry,
pharmacology* Animals Antigens, CD13 / antagonists & inhibitors*, metabolism Antigens, CD26 / metabolism* Antineoplastic Agents, Phytogenic / pharmacology Benzophenanthridines Cattle Enzyme Inhibitors / pharmacology Humans Isoquinolines Molecular Structure Papaveraceae* Phenanthridines / chemistry, pharmacology* Plant Extracts / pharmacology Protein Kinase C / antagonists & inhibitors Rats Serum Albumin / drug effects Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Antineoplastic Agents, Phytogenic; 0/Benzophenanthridines; 0/Enzyme Inhibitors; 0/Isoquinolines; 0/Phenanthridines; 0/Plant Extracts; 0/Serum Albumin; 2447-54-3/sanguinarine; 34316-15-9/chelerythrine; 41758-44-5/fagaronine; EC 2.7.11.13/Protein Kinase C; EC 3.4.11.2/Antigens, CD13; EC 3.4.14.5/Antigens, CD26 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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