Document Detail


Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents.
MedLine Citation:
PMID:  19362467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Authors:
Charles Francavilla; Eddy Low; Satheesh Nair; Bum Kim; Timothy P Shiau; Dmitri Debabov; Chris Celeri; Nichole Alvarez; Ashley Houchin; Ping Xu; Ron Najafi; Rakesh Jain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-28
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2731-4     Citation Subset:  IM    
Affiliation:
NovaBay Pharmaceuticals Inc., Emeryville, CA 94608, United States.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / chemical synthesis*,  chemistry,  pharmacology
Chloramines / chemical synthesis,  chemistry*
Microbial Sensitivity Tests
Quaternary Ammonium Compounds / chemical synthesis,  chemistry*
Structure-Activity Relationship
Sulfhydryl Compounds / chemical synthesis*,  chemistry,  pharmacology
Sulfonic Acids / chemical synthesis,  chemistry
Chemical
Reg. No./Substance:
0/2-dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt; 0/Anti-Infective Agents, Local; 0/Chloramines; 0/Quaternary Ammonium Compounds; 0/Sulfhydryl Compounds; 0/Sulfonic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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