| Quasispecies dynamics with network constraints. | |
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MedLine Citation:
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PMID: 22898555 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A quasispecies is a set of interrelated genotypes that have reached a stationary state while evolving according to the usual Darwinian principles of selection and mutation. Quasispecies studies invariably assume that it is possible for any genotype to mutate into any other, but recent finds indicate that this assumption is not necessarily true. Here we revisit the traditional quasispecies theory by adopting a network structure to constrain the occurrence of mutations. Such structure is governed by a random-graph model, whose single parameter (a probability p) controls both the graph's density and the dynamics of mutation. We contribute two further modifications to the theory, one to account for the fact that different loci in a genotype may be differently susceptible to the occurrence of mutations, the other to allow for a more plausible description of the transition from adaptation to degeneracy of the quasispecies as p is increased. We give analytical and simulation results for the usual case of binary genotypes, assuming the fitness landscape in which a genotype's fitness decays exponentially with its Hamming distance to the wild type. These results support the theory's assertions regarding the adaptation of the quasispecies to the fitness landscape and also its possible demise as a function of p. |
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Authors:
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Valmir C Barbosa; Raul Donangelo; Sergio R Souza |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-9 |
Journal Detail:
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Title: Journal of theoretical biology Volume: - ISSN: 1095-8541 ISO Abbreviation: J. Theor. Biol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Programa de Engenharia de Sistemas e Computaçáo, COPPE Universidade Federal do Rio de Janeiro Caixa Postal 68511, 21941-972 Rio de Janeiro, RJ, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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