Document Detail

Quasi-steady approximation for ion channel currents.
MedLine Citation:
PMID:  17586567     Owner:  NLM     Status:  MEDLINE    
Currents through ion channels are determined (among other parameters) by the concentration difference across the membrane containing the channel and the diffusive transport of the conducted ion toward the channel and away from it. Calculation of the current requires solving the diffusion equation around the channel. Here, we provide a quasi-steady approximation for the current and the local concentrations at the channel together with formulas linking the current and local concentrations at the channel to bulk concentrations and diffusion properties of the compartments.
K Bentele; M Falcke
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Publication Detail:
Type:  Journal Article     Date:  2007-06-22
Journal Detail:
Title:  Biophysical journal     Volume:  93     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-12-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2597-608     Citation Subset:  IM    
Department of Theory, Hahn Meitner Institute, Berlin, Germany.
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MeSH Terms
Cell Membrane / chemistry*,  physiology*
Computer Simulation
Electric Impedance
Ion Channel Gating / physiology*
Ion Channels / chemistry*,  physiology*
Membrane Potentials / physiology*
Models, Biological*
Models, Chemical*
Reg. No./Substance:
0/Ion Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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