Document Detail


Quartet: a Drosophila developmental mutation affecting chromosome separation in mitosis.
MedLine Citation:
PMID:  2193767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila mutation, quartet, affects development at points in the life cycle that require intense mitotic activity. Examination of embryos affected by the maternal effect of quartet has revealed defects that can be attributed to incomplete chromosome separation at mitosis. These defects include uneven spacing of nuclei, strands of DNA creating bridges between nuclei, and abnormal amounts of DNA per nucleus. Nuclei in quartet-affected embryos also have a greater-than-normal number of centrosomes. Immunofluorescent examination of the spindles in quartet-affected embryos has revealed tripolar spindles and adjacent spindles that share a common spindle pole. Finally, chromosome separation distance was measured in anaphase and telophase spindles in quartet-affected embryos and found to be blocked in anaphase. Examination of mitotic figures in quartet larvae revealed a reduced mitotic index and an elevated frequency of abnormal mitotic figures. quartet could encode a function necessary for the disengagement of chromosomes in mitosis, for kinetochore function or for function of a spindle motor. Mutations in quartet prevent the post-translational modification of three abundant proteins. These proteins may be involved in chromosome separation in mitosis.
Authors:
J E Zahner; C M Cheney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental genetics     Volume:  11     ISSN:  0192-253X     ISO Abbreviation:  Dev. Genet.     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-06     Completed Date:  1990-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909963     Medline TA:  Dev Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-40     Citation Subset:  IM    
Affiliation:
Department of Genetics, Washington University School of Medicine, St. Louis 63110.
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MeSH Terms
Descriptor/Qualifier:
Anaphase
Animals
Cell Nucleus / ultrastructure
Chromosomes*
DNA / genetics
Drosophila / embryology,  genetics*
Fluorescent Antibody Technique
Mitosis*
Mitotic Spindle Apparatus / ultrastructure*
Mutation*
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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