Document Detail

Quantum dots conjugated with Fe3O4 filled carbon nanotubes for cancer-targeted imaging and magnetically guided drug delivery.
MedLine Citation:
PMID:  23131026     Owner:  NLM     Status:  Publisher    
A novel and specific nanoplatform for in vitro simultaneous cancer-targeted optical imaging and magnetically-guided drug delivery is developed by conjugating CdTe quantum-dots with Fe3O4 filled carbon nanotubes (CNTs) for the first time. Fe3O4 is filled into the interior of the CNTs which facilitates magnetically guided delivery and improves the synergetic targeting efficiency. In comparison with that immobilized on the external surface of CNTs, the magnetite nanocrystals inside the CNTs protects it from agglomeration, enhances its chemical stability and improves the drug loading capacity. It also avoids magnetic nanocrystals induced quenching of fluorescence of the quantum dots. The SiO2 coated quantum dots (HQDs) attached on the surface of CNTs exhibit favorable fluorescence as the hybrid SiO2 shells on the QDs surface prevent its fluorescence quenching caused by the CNTs. In addition, the hybrid SiO2 shells also mitigate the toxicity of the CdTe QDs. By coating transferrin on the surface of the herein modified CNTs, it provides a dual-targeted drug delivery system to transport the doxorubicin hydrochloride (DOX) into Hela cells by means of an external magnetic field. The nanocarrier based on the multifunctional nanoplatform exhibits an excellent drug loading capability of ca. 110%, in addition to cancer-targeted optical imaging as well as magnetically guided drug delivery.
Mei-Ling Chen; Ye-Ju He; Xu-Wei Chen; Jian-Hua Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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