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Quantum dot-nucleic acid/aptamer bioconjugate-based fluorimetric biosensors.
MedLine Citation:
PMID:  22817707     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Over the last 10 years, fluorescent semiconductor QD (quantum dot)-biomolecule conjugates have emerged as a powerful new sensing platform showing great potential in a wide range of applications in biosensing, environmental monitoring and disease diagnosis. The present mini-review is a brief account of the recent developments in QD-NA (nucleic acid), particularly NA aptamer, conjugate-based biosensors using the FRET (Förster resonance energy transfer) readout mechanism. It starts with a brief introduction to the NA aptamer and QD-FRET, followed by example approaches to compact QD-DNA conjugates, target readout strategies and sensing performance, and concludes with challenges and outlook for the QD-NA/aptamer bioconjugate sensors.
Authors:
Dejian Zhou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  40     ISSN:  1470-8752     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  635-9     Citation Subset:  IM    
Affiliation:
School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.
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