Document Detail

The quantity of meal fat influences the profile of postprandial hormones as well as hunger sensation in healthy elderly people.
MedLine Citation:
PMID:  20188316     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In healthy elderly people, reduced appetite and the consequent decrease in food intake has been defined as the "anorexia of aging"; this condition may lead to malnutrition. The aim of this study was to investigate how different compositions of macronutrients affect satiety and hunger signals as well as subjective sensations after meals in healthy elderly subjects. METHODS: Experimental controlled study. Ambulatory healthy community-dwelling subjects evaluation in a single center on 12 elderly subjects, (75.2+/-2 years old) and 12 younger controls (28.2+/-2 years old). Using a visual analogical scale, hunger was evaluated under fasting conditions and at 30-minute intervals for up to 4 hours after two 800-kcal meals, where 20% and 40% of the calories were derived from fat. Serum samples were collected at -30, 60, 120, and 240 minutes to determine the concentrations of GLP-1, acylated and desacylated ghrelin, triglycerides, glucose, and insulin. RESULTS: Serum concentrations of GLP-1 were higher after the 40% fat meal than after the 20% fat meal (P < .01) in the elderly but not in the younger subjects. Acylated to desacylated ratio was lower after the 40% fat meal (P < .05) in the elderly. Only in the older group were triglycerides higher (P < .05), whereas hunger was significantly lower (P < .05) after the 40% fat meal. CONCLUSION: In healthy elderly people relatively large amounts of fat increase the satiety signal from GLP-1 and lower the acylated to desacylated ratio of ghrelin, consequently decreasing hunger. This condition may lead to a reduction in calorie intake.
Vincenzo Di Francesco; Rocco Barazzoni; Luisa Bissoli; Francesco Fantin; Paolo Rizzotti; Luigi Residori; Angela Antonioli; Maria Stella Graziani; Michela Zanetti; Ottavio Bosello; Gianfranco Guarnieri; Mauro Zamboni
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-18
Journal Detail:
Title:  Journal of the American Medical Directors Association     Volume:  11     ISSN:  1538-9375     ISO Abbreviation:  J Am Med Dir Assoc     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100893243     Medline TA:  J Am Med Dir Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-93     Citation Subset:  IM    
Copyright Information:
(c) 2010 American Medical Directors Association. Published by Elsevier Inc. All rights reserved.
Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy.
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MeSH Terms
Aged, 80 and over
Dietary Fats / metabolism*
Ghrelin / metabolism
Glucagon-Like Peptide 1 / blood*
Hunger / physiology*
Malnutrition / prevention & control
Satiety Response
Reg. No./Substance:
0/Dietary Fats; 0/Ghrelin; 89750-14-1/Glucagon-Like Peptide 1
Comment In:
J Am Med Dir Assoc. 2010 Mar;11(3):153-6   [PMID:  20188310 ]

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