Document Detail

Quantities of Clostridium botulinum organisms and toxin in feces and presence of Clostridium botulinum toxin in the serum of an infant with botulism.
MedLine Citation:
PMID:  6338033     Owner:  NLM     Status:  MEDLINE    
A 7-week-old boy presented with symptoms and signs characteristic of infant botulism, and the diagnosis was confirmed by the detection of Clostridium botulinum type A organisms and toxin in the feces. The levels of organisms and toxin in the feces were measured throughout the 81-day period in hospital. The maximum levels detected were 2.46 x 10(8) C. botulinum type A colony-forming units and 64,000 mouse 100% lethal doses of type A toxin per g (wet weight) of feces. C. botulinum toxin was also detected in two samples of the patient's serum, collected 3 and 10 days after admission. Improvement in the patient's clinical condition occurred before the levels of organisms and toxin in the feces reached their maxima. A slight improvement may also have occurred while toxin was still present in the serum.
J C Paton; A J Lawrence; I M Steven
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  17     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-5     Citation Subset:  IM    
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MeSH Terms
Botulinum Toxins / analysis*,  blood
Botulism / metabolism,  microbiology*
Clostridium botulinum / isolation & purification*
Feces / analysis,  microbiology*
Reg. No./Substance:
0/Botulinum Toxins

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