Document Detail

Quantitative ultrastructural studies of gall bladder epithelium in gall stone free subjects and patients with gall stones.
MedLine Citation:
PMID:  2318423     Owner:  NLM     Status:  MEDLINE    
The present study aimed at a further evaluation of the role of glycoproteins in the formation of cholesterol gall stones in man. An electron microscopic morphometric study of the gall bladder epithelium was performed in six gall stone free subjects and 12 gall stone patients. Six of the gall stone patients were treated with ursodeoxycholic acid three weeks before cholecystectomy. The number and the volume density of the mucin containing secretory granules, were not significantly increased in gall stone patients compared with gall stone free subjects. Treatment with ursodeoxycholic acid did not affect the number or volume density of the secretory granules. Thus, these results do not give evidence for that the degree of cholesterol saturation influences mucin content in the gall bladder wall of man. A major new finding was that gall stone patients had a markedly reduced total lysosome area and volume density of lysosomes compared with gall stone free subjects, a finding which may be related to a decreased intracellular degradation of protein and/or mucin.
S Sahlin; J Ahlberg; K Einarsson; R Henriksson; A Danielsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  31     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-05-02     Completed Date:  1990-05-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  100-5     Citation Subset:  AIM; IM    
Department of Surgery, Danderyd Hospital, Sweden.
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MeSH Terms
Bile / analysis
Cholelithiasis / drug therapy,  metabolism,  pathology*
Cholesterol / analysis
Cytoplasmic Granules / ultrastructure
Epithelium / ultrastructure
Gallbladder / ultrastructure*
Lysosomes / ultrastructure
Microscopy, Electron
Middle Aged
Phospholipids / analysis
Ursodeoxycholic Acid / therapeutic use
Reg. No./Substance:
0/Phospholipids; 128-13-2/Ursodeoxycholic Acid; 57-88-5/Cholesterol
Comment In:
Gut. 1990 Dec;31(12):1423   [PMID:  2088330 ]

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