Document Detail


Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice.
MedLine Citation:
PMID:  7748156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.
Authors:
R W Hyman; S Frank; C H Warden; A Daluiski; R Heller; A J Lusis
Related Documents :
18420116 - Diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly in the...
17388726 - Apoe gene deficiency enhances the reduction of bone formation induced by a high-fat die...
12584196 - Recycling of apoprotein e is associated with cholesterol efflux and high density lipopr...
20177736 - High fat diet containing cholesterol induce aortic aneurysm through recruitment and pro...
2708346 - Oxysterol regulators of 3-hydroxy-3-methylglutaryl-coa reductase in liver. effect of di...
16054086 - Role of premature leptin surge in obesity resulting from intrauterine undernutrition.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical genetics     Volume:  32     ISSN:  0006-2928     ISO Abbreviation:  Biochem. Genet.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-06-09     Completed Date:  1995-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-407     Citation Subset:  IM    
Affiliation:
Stanford DNA Sequence and Technology Center, Stanford University School of Medicine, California 94305, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoprotein A-I / blood
Apolipoprotein A-II / blood
Arteriosclerosis / blood,  etiology,  genetics*
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, VLDL / blood
Diet, Atherogenic*
Genetic Predisposition to Disease
Mice
Mice, Inbred C3H / genetics*
Mice, Inbred C57BL / genetics*
Phenotype
Probability
Recombination, Genetic*
Species Specificity
Grant Support
ID/Acronym/Agency:
HL-30568/HL/NHLBI NIH HHS; HL-42488/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Cholesterol, HDL; 0/Cholesterol, VLDL; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  T4 phage evolution data in terms of a time-dependent Topal-Fresco mechanism.
Next Document:  Biochemical genetic studies on wild populations of three species of green leafhoppers, Nephotettix, ...