Document Detail

Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice.
MedLine Citation:
PMID:  7748156     Owner:  NLM     Status:  MEDLINE    
Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.
R W Hyman; S Frank; C H Warden; A Daluiski; R Heller; A J Lusis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical genetics     Volume:  32     ISSN:  0006-2928     ISO Abbreviation:  Biochem. Genet.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-06-09     Completed Date:  1995-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-407     Citation Subset:  IM    
Stanford DNA Sequence and Technology Center, Stanford University School of Medicine, California 94305, USA.
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MeSH Terms
Apolipoprotein A-I / blood
Apolipoprotein A-II / blood
Arteriosclerosis / blood,  etiology,  genetics*
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, VLDL / blood
Diet, Atherogenic*
Genetic Predisposition to Disease
Mice, Inbred C3H / genetics*
Mice, Inbred C57BL / genetics*
Recombination, Genetic*
Species Specificity
Grant Support
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Cholesterol, HDL; 0/Cholesterol, VLDL; 57-88-5/Cholesterol

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