Document Detail


Quantitative trait locus analysis in crosses between outbred lines with dominance and inbreeding.
MedLine Citation:
PMID:  11560915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We provide a theoretical framework for quantitative trait locus (QTL) analysis of a crossed population where parental lines may be outbred and dominance as well as inbreeding are allowed for. It can be applied to any pedigree. A biallelic QTL is assumed, and the QTL allele frequencies can be different in each breed. The genetic covariance between any two individuals is expressed as a nonlinear function of the probability of up to 15 possible identity modes and of the additive and dominance effects, together with the allelic frequencies in each of the two parental breeds. The probabilities of each identity mode are obtained at the desired genome positions using a Monte Carlo Markov chain method. Unbiased estimates of the actual genetic parameters are recovered in a simulated F(2) cross and in a six-generation complex pedigree under a variety of genetic models (allele fixed or segregating in the parental populations and additive or dominance action). Results from analyzing an F(2) cross between Meishan and Large White pigs are also presented.
Authors:
M Pérez-Enciso; R L Fernando; J P Bidanel; P Le Roy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics     Volume:  159     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-18     Completed Date:  2002-01-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-22     Citation Subset:  IM    
Affiliation:
INRA, Station d'Amélioration Génétique des Animaux, BP 27, 31326 Castanet-Tolosan, France. mperez@toulouse.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Crosses, Genetic*
Gene Frequency
Genes, Dominant
Inbreeding
Likelihood Functions
Markov Chains
Models, Genetic
Models, Statistical
Monte Carlo Method
Multivariate Analysis
Pedigree
Phenotype
Quantitative Trait, Heritable*
Swine
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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