Document Detail

Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.
MedLine Citation:
PMID:  11074014     Owner:  NLM     Status:  MEDLINE    
Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR x C57L) F(1) x AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones and mice having the largest stones were genotyped at approximately 20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK. L-Lith1(s). Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L-Lith2(s). Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.
B Paigen; N J Schork; K L Svenson; Y C Cheah; J L Mu; F Lammert; D Q Wang; G Bouchard; M C Carey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2000-11-09
Journal Detail:
Title:  Physiological genomics     Volume:  4     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2001-02-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
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MeSH Terms
Cholelithiasis / genetics*
Cholesterol* / genetics
Cholesterol, Dietary / adverse effects
Chromosome Mapping* / methods
Crosses, Genetic
Gallbladder / chemistry,  physiopathology
Genetic Markers
Genetic Predisposition to Disease / genetics
Mice, Inbred AKR
Mice, Inbred C57BL
Organ Size / genetics
Quantitative Trait, Heritable*
Grant Support
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Genetic Markers; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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