Document Detail


Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.
MedLine Citation:
PMID:  11074014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR x C57L) F(1) x AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones and mice having the largest stones were genotyped at approximately 20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK. L-Lith1(s). Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L-Lith2(s). Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.
Authors:
B Paigen; N J Schork; K L Svenson; Y C Cheah; J L Mu; F Lammert; D Q Wang; G Bouchard; M C Carey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2000-11-09
Journal Detail:
Title:  Physiological genomics     Volume:  4     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2001-02-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. bjp@jax.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholelithiasis / genetics*
Cholesterol* / genetics
Cholesterol, Dietary / adverse effects
Chromosome Mapping* / methods
Crosses, Genetic
Gallbladder / chemistry,  physiopathology
Genetic Markers
Genetic Predisposition to Disease / genetics
Male
Mice
Mice, Inbred AKR
Mice, Inbred C57BL
Organ Size / genetics
Quantitative Trait, Heritable*
Grant Support
ID/Acronym/Agency:
DK-34854/DK/NIDDK NIH HHS; DK-36588/DK/NIDDK NIH HHS; DK-51568/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Genetic Markers; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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