Document Detail

Quantitative thallium-201 scintigraphy after dipyridamole infusion combined with low level exercise in healthy volunteers.
MedLine Citation:
PMID:  2759124     Owner:  NLM     Status:  MEDLINE    
To establish test specific normal limits for quantitative analysis of uptake and washout of 201Tl after dipyridamole infusion combined with low level exercise, 20 healthy volunteers were studied with low likelihood of coronary artery disease (CAD) assessed by a stepwise probability analysis based on age, sex, symptoms, resting electrocardiogram, and exercise electrocardiography. Likelihood of CAD in these volunteers was calculated as less than or equal to 1%. After dipyridamole infusion combined with low level exercise, one volunteer complained of headache; no other side effects were observed. There were no chest pain complaints. Maximal hemodynamic changes were achieved during the 6th and 7th min of the test. No ST segment depression was recorded. Visual analysis of the 201Tl scintigrams was normal in all volunteers. Mean regional washout at 4 h was 44.37% +/- 2.11%. The regional washout in the 70 degrees LAO view (46.65% +/- 1.10%) was significantly higher than in the anterior and 30 degrees LAO views (43.44% +/- 1.50% and 43.02% +/- 1.45%, respectively). Profiles of uptake and washout of 201Tl were different after dipyridamole infusion combined with low level exercise as compared to maximal exercise. Thus, in quantitative analysis of 201Tl scintigraphy after dipyridamole infusion in conjunction with low level exercise as applied in the present study, it is mandatory to use normal limits of uptake and washout of 201Tl derived from healthy volunteers who underwent the same combined protocol.
G J Laarman; M G Niemeyer; A V Bruschke; F J Verzijlbergen; T L Go; E E van der Wall; C A Ascoop
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  15     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-20     Completed Date:  1989-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Department of Cardiology St. Antonius Hospital, Nieuwegein, The Netherlands.
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MeSH Terms
Blood Pressure
Coronary Disease / radionuclide imaging
Dipyridamole / adverse effects,  diagnostic use*
Heart / radionuclide imaging*
Heart Function Tests / methods
Heart Rate
Reference Values
Thallium Radioisotopes / diagnostic use*,  pharmacokinetics
Reg. No./Substance:
0/Thallium Radioisotopes; 58-32-2/Dipyridamole

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