Document Detail

Quantitative study of the precancerous and malignant lesions in colorectal adenomas.
MedLine Citation:
PMID:  1409089     Owner:  NLM     Status:  MEDLINE    
150 endoscopically removed colorectal adenomas are quantitatively studied. In 90 cases dysplastic glands constituted the entire lesion (30 mild, 30 moderate, 30 severe); in 60 cases foci of adenocarcinoma were present (30 intramucosal, 30 submucosal). In each case the area, the perimeter and the integrated optical density of 100 nuclei were measured from Feulgen-stained paraffin sections. The results show a continuous neoplastic progression in the trends of the morphometric parameters as well as in the ploidy pattern. The stepwise discriminant analysis defined the morphometric features of the atypical nuclei, which were present in small numbers also in mild dysplasia; they progressively increased in number, reaching the maximum in submucosal carcinoma.
R Ranaldi; I Bearzi; A Santinelli; B Mannello; G M Mariuzzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  188     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-11-12     Completed Date:  1992-11-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  561-4     Citation Subset:  IM    
Istituto di Anatomia ed Istologia Patologica, Università degli Studi di Ancona, Italy.
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MeSH Terms
Adenocarcinoma / genetics,  pathology*
Adenoma / genetics,  pathology*
Colorectal Neoplasms / genetics,  pathology*
DNA, Neoplasm / analysis,  genetics
Precancerous Conditions / genetics,  pathology*
Reg. No./Substance:
0/DNA, Neoplasm

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