Document Detail

Quantitative study of behavioral disturbances in rats exposed to high pressure.
MedLine Citation:
PMID:  1910348     Owner:  NLM     Status:  MEDLINE    
When human divers or experimental animals are exposed to high pressure, they develop the High Pressure Neurological Syndrome (HPNS). Male Sprague-Dawley rats were exposed to high pressure in a conventional helium-oxygen breathing mixture to 80 bars. Pressure-induced behavioral motor disturbances including hyperlocomotor activity (HLA), tremor and myoclonia were monitored with a noninvasive piezoelectrical sensor device enabling a without discontinuity long-term analysis. New data were obtained on the development of the HPNS behavioral motor disturbances. Indeed, the present results suggest myoclonia would be more sensitive to constant high pressure exposure, while HLA and tremor would be more sensitive to increasing pressure. Moreover, myoclonia were found to occur significantly later in rats which developed epileptic seizures than in other. The present results constitute the quantitative basis of HPNS motor disturbances for future pharmacological pressure experiments.
J H Abraini; C Tomei; J C Rostain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of physiological anthropology = Seiri Jinruigaku Kenkyūkai kaishi     Volume:  10     ISSN:  0287-8429     ISO Abbreviation:  Ann Physiol Anthropol     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-21     Completed Date:  1991-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506625     Medline TA:  Ann Physiol Anthropol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Laboratoire de biologie des hautes pressions, CNRS URA 1330, Faculté de médecine nord., Marseille, France.
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MeSH Terms
Behavior, Animal
High Pressure Neurological Syndrome / etiology*
Motor Activity
Pressure / adverse effects*
Rats, Inbred Strains

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