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Quantitative structure-activity relationships of insecticides and plant growth regulators: comparative studies toward understanding the molecular mechanism of action.
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MedLine Citation:
PMID:  3905379     Owner:  NLM     Status:  MEDLINE    
Emphasis was put on the comparative quantitative structure-activity approaches to the exploration of action mechanisms of structurally different classes of compounds showing the same type of activity as well as those of the same type of compounds having different actions. Examples were selected from studies performed on insecticides and plant growth regulators, i.e., neurotoxic carbamates, phosphates, pyrethroids and DDT analogs, insect juvenile hormone mimics, and cytokinin agonistic and antagonistic compounds. Similarities and dissimilarities in structures required to elicit activity between compounds classes were revealed in terms of physicochemical parameters, provoking further exploration and evoking insights into the molecular mechanisms of action which may lead to the development of new structures having better qualities.
H Iwamura; K Nishimura; T Fujita
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  61     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-15     Completed Date:  1986-01-15     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-20     Citation Subset:  IM    
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MeSH Terms
Adenine / pharmacology
Cholinesterase Inhibitors / pharmacology
Cytokinins / pharmacology
DDT / pharmacology
Insecticides / pharmacology*
Plant Growth Regulators / pharmacology*
Pyrethrins / pharmacology
Pyrimidines / pharmacology
Structure-Activity Relationship
Urea / pharmacology
Reg. No./Substance:
0/Carbamates; 0/Cholinesterase Inhibitors; 0/Cytokinins; 0/Insecticides; 0/Plant Growth Regulators; 0/Pyrethrins; 0/Pyrimidines; 50-29-3/DDT; 57-13-6/Urea; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 9 Year: 1985
Volume: 61First Page: 307 Last Page: 320
ID: 1568746
PubMed Id: 3905379

Quantitative structure-activity relationships of insecticides and plant growth regulators: comparative studies toward understanding the molecular mechanism of action.
H Iwamura
K Nishimura
T Fujita

Article Categories:
  • Research Article

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