| Quantitative spectroscopy of superficial turbid media. | |
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MedLine Citation:
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PMID: 16350274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a novel diffuse optical spectroscopy probe design for determining optical properties of superficial volumes of turbid samples. The fiber-based probe employs a highly scattering layer placed in contact with the sample of interest. This layer diffuses photons from a collimated light source before they enter the sample and provides a basis for describing light transported in superficial media by the diffusion approximation. We compare the performance of this modified two-layer diffusion model with Monte Carlo simulations. A set of experiments that demonstrate the feasibility of this method in turbid tissue phantoms is also presented. Optical properties deduced by this approach are in good agreement with those derived by use of a benchmark method for determining optical properties. The average interrogation depth of the probe design investigated here is estimated to be less than 1 mm. |
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Authors:
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Sheng-Hao Tseng; Carole Hayakawa; Bruce J Tromberg; Jerome Spanier; Anthony J Durkin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Optics letters Volume: 30 ISSN: 0146-9592 ISO Abbreviation: Opt Lett Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-02-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3165-7 Citation Subset: IM |
Affiliation:
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Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine 92617, USA. shenghat@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Equipment Design Equipment Failure Analysis Fiber Optic Technology / instrumentation* Image Enhancement / instrumentation*, methods Nephelometry and Turbidimetry / instrumentation*, methods Reproducibility of Results Sensitivity and Specificity Spectrum Analysis / instrumentation*, methods Transducers* |
| Grant Support | |
ID/Acronym/Agency:
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P41-RR01192/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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