| Quantitative sensory examination of epidural anaesthesia and analgesia in man: combination of morphine and bupivacaine. | |
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MedLine Citation:
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PMID: 8022626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of epidural administration of a combination of low-dose morphine (2 mg) and bupivacaine (25 mg) on somatosensory and motor functions was examined in 13 healthy volunteers. The study design was a double-blind 4-way cross-over in which combined treatment was compared with either drug used alone or placebo. Every 2nd hour for 10 h effects on nociceptive and non-nociceptive somatosensory functions were quantified with 12 psychophysical measures. In addition knee extension strength, reaction time and skin temperature were examined. Epidural bupivacaine had hypoalgesic effect in all nociceptive tests, whereas epidural morphine only demonstrated hypoalgesic properties in nociceptive test with prolonged stimuli. In comparison with bupivacaine alone the combination treatment had a lesser peak effect but a more prolonged hypoalgesic action. In comparison with morphine alone the combination treatment induced a faster onset and demonstrated a modest increase in hypoalgesic effect in a subset of the test, even beyond the duration of bupivacaine when administered alone. Motor function was not attenuated by any of the treatments. Mechanisms of interaction between morphine and bupivacaine as well as their possible clinical implications are discussed. |
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Authors:
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J Brennum; K L Petersen; A Horn; L Arendt-Nielsen; N H Secher; T S Jensen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pain Volume: 56 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-07-29 Completed Date: 1994-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 327-37 Citation Subset: IM |
Affiliation:
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Department of Neurology, Gentofte Hospital, Hellerup, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analgesia, Epidural* Anesthesia, Epidural* Bupivacaine / administration & dosage, adverse effects, pharmacology* Double-Blind Method Drug Therapy, Combination Electric Stimulation Female Humans Male Morphine / administration & dosage, adverse effects, pharmacology* Pain Measurement / drug effects* Pain Threshold / drug effects Physical Stimulation Reaction Time / drug effects Sensory Thresholds / drug effects Skin Temperature / drug effects |
| Chemical | |
Reg. No./Substance:
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2180-92-9/Bupivacaine; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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