Document Detail

Quantitative segmentation of principal carotid atherosclerotic lesion components by feature space analysis based on multicontrast MRI at 1.5 T.
MedLine Citation:
PMID:  19272944     Owner:  NLM     Status:  MEDLINE    
The purpose of this paper is to evaluate the capability of feature space analysis (FSA) for quantifying the relative volumes of principal components (thrombus, calcification, fibrous, normal intima, and lipid) of atherosclerotic plaque tissue in multicontrast magnetic resonance images (mc-MRI) acquired in a setup resembling clinical conditions ex vivo. Utilizing endogenous contrast, proton density, T1-weighted, and T2-weighted images were acquired for 13 carotid endarterectomy (CEA) tissues under near-clinical conditions (human 1.5 T GE Excite scanner with sequence parameters comparable to an in vivo acquisition). An FSA algorithm was utilized to segment and quantify the principal components of atherosclerotic plaques. Pilot in vivo mc-MRI images were analyzed in the same way as the ex vivo images for exploring the possible adaptation of this technique to in vivo imaging. Relative abundance of principal plaque components in CEA tissues as determined by mc-MRI/FSA were compared to those measured by histology. Mean differences +/- standard deviations were 5.8 +/- 4.1% for thrombus, 1.5 +/-1.4 % for calcification, 4.0 +/-2.8% for fibrous, 8.2 +/- 10% for normal intima, and 2.4 +/- 2.2% for lipid. Reasonable quantitative agreement between the classification results obtained with FSA and histological data was obtained for near-clinical imaging conditions. Combination of mc-MRI and FSA may have an application for determining atherosclerotic lesion composition and monitoring treatment in vivo.
Christof Karmonik; Pamela Basto; Kasey Vickers; Kirt Martin; Micheal J Reardon; Gerald M Lawrie; Joel D Morrisett
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Publication Detail:
Type:  Journal Article     Date:  2008-10-31
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  56     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-04-03     Completed Date:  2009-09-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-60     Citation Subset:  IM    
Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA.
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MeSH Terms
Atherosclerosis / pathology*
Carotid Stenosis / pathology*
Cluster Analysis
Coloring Agents
Histological Techniques
Magnetic Resonance Imaging / methods*
Models, Cardiovascular
Signal Processing, Computer-Assisted*
Reg. No./Substance:
0/Coloring Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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