Document Detail


Quantitative risk assessment: state-of-the-art for carcinogenesis.
MedLine Citation:
PMID:  6628895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A critical evaluation of the use of statistical models in carcinogenic risk assessment is made with emphasis on the strengths and weaknesses of current practice. The objective is to bring together information from the fields of toxicology and statistics to develop a sound scientific basis for making risk decisions. It is emphasized that risk assessment is a complex, multifaceted process that is not easily quantified and, at present, must be based on qualitative as well as quantitative information. It is evident that dose-response modeling of tumor incidence data from animal studies is of limited value in estimating human risk associated with low-dose chemical exposures. The models take into account only one part of the complex process and have no accepted basis in biology. The key decision points, qualitative factors, and quantitative considerations are identified and discussed and a risk assessment framework that incorporates these inputs is presented. A model that incorporates the tumorigenic dose-response information as well as the qualitative and quantitative biological factors that affect the estimate of risk is proposed. It is concluded that much work needs to be done before a completely quantitative approach to risk assessment is to be useful; in particular pharmacokinetic modeling should be pursued more aggressively.
Authors:
C N Park; R D Snee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  3     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:    1983 Jul-Aug
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  320-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogens* / metabolism
Humans
Kinetics
Models, Theoretical
Risk
Species Specificity
Statistics as Topic
Teratogens
Toxicology / methods*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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