Document Detail

Quantitative right and left ventricular functional analysis during gated whole-chest MDCT: a feasibility study comparing automatic segmentation to semi-manual contouring.
MedLine Citation:
PMID:  19540692     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the feasibility of an automatic, whole-heart segmentation algorithm for measuring global heart function from gated, whole-chest MDCT images.
MATERIAL AND METHODS: 15 patients with suspicion of PE underwent whole-chest contrast-enhanced MDCT with retrospective ECG synchronization. Two observers computed right and left ventricular functional indices using a semi-manual and an automatic whole-heart segmentation algorithm. The two techniques were compared using Bland-Altman analysis and paired Student's t-test. Measurement reproducibility was calculated using intraclass correlation coefficient.
RESULTS: Ventricular analysis with automatic segmentation was successful in 13/15 (86%) and in 15/15 (100%) patients for the right ventricle and left ventricle, respectively. Reproducibility of measurements for both ventricles was perfect (ICC: 1.00) and very good for automatic and semi-manual measurements, respectively. Ventricular volumes and functional indices except right ventricular ejection fraction obtained from the automatic method were significantly higher for the RV compared to the semi-manual methods.
CONCLUSIONS: The automatic, whole-heart segmentation algorithm enabled highly reproducible global heart function to be rapidly obtained in patients undergoing gated whole-chest MDCT for assessment of acute chest pain with suspicion of pulmonary embolism.
Emmanuel Coche; Matthew J Walker; Francis Zech; Rodolphe de Crombrugghe; Alain Vlassenbroek
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-06-21
Journal Detail:
Title:  European journal of radiology     Volume:  74     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e138-43     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Medical Imaging, Université Catholique de Louvain, Cliniques Universitaires St-Luc (UCL), Avenue Hippocrate, 10, 1200 Brussels, Belgium.
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MeSH Terms
Aged, 80 and over
Cardiac-Gated Imaging Techniques / methods*
Feasibility Studies
Middle Aged
Observer Variation
Pattern Recognition, Automated / methods*
Radiographic Image Enhancement / methods
Radiographic Image Interpretation, Computer-Assisted / methods*
Radiography, Thoracic / methods*
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed / methods*
Ventricular Dysfunction, Left / complications,  radiography*
Ventricular Dysfunction, Right / complications,  radiography*

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