| Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: comparison with rest-redistribution thallium-201. | |
| | |
MedLine Citation:
|
PMID: 9137217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: This study was undertaken to 1) compare the regional myocardial tracer distributions between rest technetium (Tc)-99m tetrofosmin and rest-redistribution thallium (Tl)-201 images in patients with coronary artery disease and left ventricular dysfunction; and 2) assess the comparative values of these agents for predicting functional recovery after revascularization. BACKGROUND: Tc-99m tetrofosmin is a new myocardial perfusion imaging agent, but its role for detecting viable myocardium is still unclear. METHODS: Thirty-six patients with coronary artery disease and left ventricular dysfunction underwent rest Tc-99m tetrofosmin, rest-redistribution Tl-201 and gated blood pool scintigraphy. In 21 patients with successful revascularization confirmed by follow-up angiography, gated blood pool scintigraphy was repeated after revascularization. Optimal threshold cutoffs to separate reversible from irreversible dysfunction were determined by receive operating characteristic analysis. RESULTS: Regional Tc-99m tetrofosimin activity highly correlated with redistribution Tl-201 activity (r = 0.93). The diagnostic performance for predicting functional recovery, as measured by the area under the receiver operating characteristic curves, measured 0.66 +/- 0.07 (mean +/- SD) for Tc-99m tetrofosmin and 0.67 +/- 0.07 for Tl-201 (p = 0.60, 96.7% power to detect difference in area of 0.10). The optimal threshold cutoffs for viability were considered to be 50% of peak activity for Tc-99m tetrofosmin and 55% of peak activity for Tl-201. The positive and negative predictive values for reversible dysfunction were, respectively, 69% and 82% for Tc-99m tetrofosmin and 69% (p = 0.99 vs. Tc-99m tetrofosmin) and 71% (p = 0.66 vs. Tc-99m tetrofosmin) by Tl-201. CONCLUSIONS: The diagnostic performance of quantitative rest Tc-99m tetrofosmin imaging in predicting functional recovery after revascularization is comparable to that of rest-redistribution Tl-201. |
| | |
Authors:
|
I Matsunari; S Fujino; J Taki; J Senma; T Aoyama; T Wakasugi; J Hirai; T Saga; S Yamamoto; N Tonami |
Related Documents
:
|
14613737 - Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in ... 15159617 - Long-term change in size of cerebral infarction: predictive value of brain perfusion sp... 7994667 - Critical stenoses of the left anterior descending artery: predominant role in stress-in... 3494967 - Functional mapping of ventricular contraction and phase using single-photon emission co... 9540127 - Hypertension-induced congestive heart failure. 2251987 - Prehospital thrombolysis in acute myocardial infarction. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 29 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1997 May |
Date Detail:
|
Created Date: 1997-06-03 Completed Date: 1997-06-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1226-33 Citation Subset: AIM; IM |
Affiliation:
|
Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Transluminal, Percutaneous Coronary Case-Control Studies Coronary Artery Bypass Coronary Disease / radionuclide imaging*, therapy* Female Gated Blood-Pool Imaging Heart / radionuclide imaging* Humans Male Middle Aged Organophosphorus Compounds / diagnostic use* Organotechnetium Compounds / diagnostic use* Predictive Value of Tests Prospective Studies ROC Curve Radiopharmaceuticals / diagnostic use Thallium Radioisotopes / diagnostic use* Tomography, Emission-Computed, Single-Photon Ventricular Dysfunction, Left / radionuclide imaging, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnosis of coronary artery disease by exercise thallium-201 tomography in patients with a right ve...
Next Document: Evolution of dobutamine echocardiography protocols and indications: safety and side effects in 3,011...