Document Detail

Quantitative relationships between structure and antimicrobial activity of new "soft" bisquaternary ammonium salts.
MedLine Citation:
PMID:  7995599     Owner:  NLM     Status:  MEDLINE    
New surface-active bisquaternary ammonium salts derived from bis-(2-dimethylaminoethyl) ester of glutaric acid are highly effective against representatives of Gram-positive, Gram-negative bacteria and yeasts. Relationships between structure, lipophilicity and antimicrobial effectiveness were demonstrated by quantitative structure-activity methodology. The non-linear dependence of biological activity on the structure as well as lipophilicity (expressed as critical micelle concentration-CMC) was shown using Kubinyi's bilinear model. The most effective compounds were those with the alkyl chain of 11-12 carbon atoms and with the CMC values around 0.7-1.0 mmol/L. These derivatives possessed higher antimicrobial activity particularly to Gram-negative bacteria.
M Pavlíková-Morická; I Lacko; F Devínsky; L Masárová; D Milynarcík
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia microbiologica     Volume:  39     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-13     Completed Date:  1995-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  IM    
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
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MeSH Terms
Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis,  pharmacology*
Antifungal Agents / chemical synthesis,  pharmacology*
Candida albicans / drug effects
Escherichia coli / drug effects
Microbial Sensitivity Tests
Quaternary Ammonium Compounds / pharmacology*
Staphylococcus aureus / drug effects
Structure-Activity Relationship
Surface-Active Agents / pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Antifungal Agents; 0/Quaternary Ammonium Compounds; 0/Surface-Active Agents

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