Document Detail

Quantitative relationships between hydrophobicity and hypotensive activity of diazacycloalkane derivatives.
MedLine Citation:
PMID:  2485909     Owner:  NLM     Status:  MEDLINE    
The effect of a series of ten newly synthesized diazacycloalkanes as well as four standard imidazoline drugs on blood pressure of anesthetized normotensive rats was measured. The hypotensive activity of the agents studied, expressed as logit of the maximum effect, logit E(%), was quantitatively related to the changes in their chemical structure. Highly significant relationship between the hydrophobicity parameter, sigma f, and logit E(%) value has been found.
A Nasal; R Kaliszan; H Foks; K Wisterowicz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology and pharmacy     Volume:  41     ISSN:  0301-0244     ISO Abbreviation:  Pol J Pharmacol Pharm     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-12-13     Completed Date:  1990-12-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0366561     Medline TA:  Pol J Pharmacol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  649-57     Citation Subset:  IM    
Biopharmaceutics and Pharmacodynamics Unit, Medical Academy, Gdańsk, Poland.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Chemistry, Physical
Chromatography, Thin Layer
Imidazoles / pharmacology*
Physicochemical Phenomena
Pyrazines / pharmacology*
Rats, Inbred Strains
Structure-Activity Relationship
Reg. No./Substance:
0/Antihypertensive Agents; 0/Imidazoles; 0/Pyrazines

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