Document Detail


Quantitative rapid steady state T(1) magnetic resonance imaging for cerebral blood volume mapping in mice: Lengthened measurement time window with intraperitoneal Gd-DOTA injection.
MedLine Citation:
PMID:  22760854     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This work demonstrates how the rapid steady state T(1) MRI technique for cerebral blood volume fraction (BVf) quantification can be used with intraperitoneal Gd-DOTA injections in mice at 4.7 T. The peak signal amplitude after intravenous administration (0.7 mmol/kg) and the steady state signal amplitude reached 15 min after intraperitoneal administration (6 mmol/kg) in the same mice lead to equivalent BVf measures in the order of 0.02 in the brain. The resulting time window for BVf quantification is ≈30 min and allows for cerebral BVf mapping with increased spatial resolution or signal-to-noise ratio, or for monitoring functional BVf changes. A cerebral BVf increase of up to 25% induced by the vasodilator acetazolamide was observed, validating the vascular origin of the signal. The noninvasive and quantitative rapid steady state T(1) technique can be used in serial studies to evaluate new drugs or disease models, such as antiangiogenic therapies in tumors. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
Authors:
Adriana T Perles-Barbacaru; François Berger; Hana Lahrech
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-3
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Université Joseph Fourier, Grenoble Institut des Neurosciences, F-38042, Grenoble, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U836, F-38042, Grenoble, France. adriana.perles@ujf-grenoble.fr.
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