Document Detail


Quantitative and qualitative changes in the resting electrocardiograph after percutaneous transluminal septal myocardial ablation for the treatment of symptomatic obstructive hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  18657474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Percutaneous Transluminal Septal Myocardial Ablation (PTSMA) may reduce symptoms in patients with obstructive hypertrophic cardiomyopathy. Limited quantitative and qualitative data exists on the effects of PTSMA on the resting electrocardiograph. We report repolarisation and conduction abnormalities and incidence of arrhythmia post-PTSMA. Twelve-lead electrocardiographs from subjects without pre-procedural pacemakers who underwent successful procedures (37 procedures, mean age 61+/-14 years) were analysed for rhythm, heart rate, PR and QTc intervals, QRS duration and left or right bundle branch block (RBBB, LBBB). Four subjects developed permanent complete AV block, 19 subjects developed new RBBB and two subjects developed new LBBB pre-discharge. At a median follow-up of 34 (range 1-84) months, no new AV block, ventricular arrhythmias or deaths occurred. Post-PTSMA PR, QRS and QTc intervals lengthened (PR 180+/-33 ms, 204+/-40 ms, QRS 105+/-20 ms, 132+/-27 ms and QTc 454+/-32 ms, 491+/-37 ms (pre- and post-PTSMA respectively, all p=0.001). Predictors of permanent complete AV block included female gender (p=0.013), older age (p=0.013) and pre-existing LBBB (p<0.001). Atrio-ventricular and intra-ventricular conduction disturbances are common post-PTSMA. A pre-existing LBBB is a risk factor for the development of complete AV block and may merit prophylactic pacemaker insertion.
Authors:
Wai-ee Thai; Paul R Antonis; Sarah A Hope; Ian T Meredith
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Publication Detail:
Type:  Journal Article     Date:  2008-07-26
Journal Detail:
Title:  Heart, lung & circulation     Volume:  17     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2008-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  IM    
Affiliation:
Monash Cardiovascular Research Centre, MonashHeart, Southern Health, 246 Clayton Road, Clayton, Victoria 3168, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Bundle-Branch Block / etiology*,  mortality,  physiopathology*
Cardiomyopathy, Hypertrophic / mortality,  therapy*
Catheter Ablation / adverse effects*,  methods
Electrocardiography*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Pacemaker, Artificial
Risk Factors
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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