Document Detail

Quantitative polymerase chain reaction analysis of fungi in dust from homes of infants who developed idiopathic pulmonary hemorrhaging.
MedLine Citation:
PMID:  15213523     Owner:  NLM     Status:  MEDLINE    
Fungal concentrations were measured in the dust of 6 homes in Cleveland, Ohio, where an infant developed pulmonary hemorrhage (pulmonary hemorrhage homes [PHH]) and 26 reference homes (RH) with no known fungal contamination. Quantitative polymerase chain reaction assays for 82 species (or assay groups) were used to identify and quantify fungal concentrations. The ratios of the geometric means of PHH to RH were >1 for 26 species (group I). However, the same ratios were <1 for 10 species (group II). Probit analysis of the sum of the logs of the concentrations of these 2 groups resulted in a 95% probability range for separating PHH from RH homes. The same 82 fungal species were also tested for hemolysin production on sheep's blood agar (incubated at 37 degree C). Hemolysins were more commonly produced by group I species (42%) compared with group II species (10%).
Stephen J Vesper; Manju Varma; Larry J Wymer; Dorr G Dearborn; John Sobolewski; Richard A Haugland
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  46     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-23     Completed Date:  2004-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  596-601     Citation Subset:  IM    
US Environmental Protection Agency, National Exposure Research Laboratory, Cincinnati, Ohio 45268, USA.
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MeSH Terms
Air Microbiology
Air Pollution, Indoor / adverse effects*
Case-Control Studies
Dust / analysis*
Fungi / classification,  genetics*,  pathogenicity
Hemolysin Proteins / analysis
Hemorrhage / microbiology*
Infant, Newborn
Logistic Models
Lung / physiopathology
Lung Diseases, Fungal / microbiology*
Polymerase Chain Reaction
Reg. No./Substance:
0/Dust; 0/Hemolysin Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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