Document Detail

Quantitative phenotyping of chromatic dysfunction in best macular dystrophy.
MedLine Citation:
PMID:  16009836     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To quantify chromatic dysfunction in Best disease to reassess the classic categorization of macular chromatic damage and to investigate psychophysical and clinical correlations. METHODS: Color-contrast discrimination was measured using 2 different psychophysical strategies in age-matched control (n = 41) and patient (n = 34) eyes. The first strategy measured performance along 3 main confusion lines (testing cone function), and the second evaluated discrimination ellipses (modified Cambridge Color Test). The main outcome measures were chromatic discrimination variables (confusion line length, ellipse length, angle, and axis ratio) and visual acuity (VA). RESULTS: Significant loss of performance was seen in all color axes in our patients, and it increased monotonically with staging, becoming significant in Fishman stages 2 and 3. The classically assumed preferential type I red-green deficit was true only for stage 4. Substantial chromatic dysfunction occurred even with relatively preserved VA despite that negative correlations between all test variables and VA reached statistical significance. Partial correlation analysis showed that protan/deutan loss was related to VA independent of tritan loss. Statistically significant positive correlations were also found between lesion size and chromatic dysfunction. CONCLUSIONS: Chromatic discrimination is often impaired in Best disease, even when VA is still spared. Our quantitative psychophysical approach shows that the classic categorization as a type I red-green deficit is valid only for disease stage 4.
Sónia H Campos; Vasco Forjaz; Lajos R Kozak; Eduardo Silva; Miguel Castelo-Branco
Related Documents :
11704036 - Clinical spectrum of posterior ischemic optic neuropathy.
18061266 - Monovision in lasik.
17564186 - Anterior clinoidal mucocele causing optic neuropathy: resolution with nonsurgical thera...
2226986 - Screening for hydroxychloroquine retinal toxicity: is it necessary?
17354026 - Intrathyroid parathyroid adenoma in primary hyperparathyroidism: can it be predicted pr...
21145776 - Investigation of effects of different treatment modalities on structural and functional...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  123     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-07-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  944-9     Citation Subset:  AIM; IM    
Center for Ophthalmology, Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Az. de Sta Comba, Celas 3000-354, Coimbra, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Color Perception Tests / methods
Color Vision Defects / diagnosis*,  physiopathology
Contrast Sensitivity
Macular Degeneration / diagnosis*,  physiopathology
Psychophysiology / methods
Retinal Cone Photoreceptor Cells / physiopathology
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A standardized method for reporting changes in macular thickening using optical coherence tomography...
Next Document:  Effects of scleral buckling without encircling procedures on retrobulbar hemodynamics as measured by...