Document Detail

Quantitative parametric MRI of articular cartilage: a review of progress and open challenges.
MedLine Citation:
PMID:  23407427     Owner:  NLM     Status:  MEDLINE    
With increasing life expectancies and the desire to maintain active lifestyles well into old age, the impact of the debilitating disease osteoarthritis (OA) and its burden on healthcare services is mounting. Emerging regenerative therapies could deliver significant advances in the effective treatment of OA but rely upon the ability to identify the initial signs of tissue damage and will also benefit from quantitative assessment of tissue repair in vivo. Continued development in the field of quantitative MRI in recent years has seen the emergence of techniques able to probe the earliest biochemical changes linked with the onset of OA. Quantitative MRI measurements including T(1), T(2) and T(1ρ) relaxometry, diffusion weighted imaging and magnetisation transfer have been studied and linked to the macromolecular structure of cartilage. Delayed gadolinium-enhanced MRI of cartilage, sodium MRI and glycosaminoglycan chemical exchange saturation transfer techniques are sensitive to depletion of cartilage glycosaminoglycans and may allow detection of the earliest stages of OA. We review these current and emerging techniques for the diagnosis of early OA, evaluate the progress that has been made towards their implementation in the clinic and identify future challenges in the field.
D A Binks; R J Hodgson; M E Ries; R J Foster; S W Smye; D McGonagle; A Radjenovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The British journal of radiology     Volume:  86     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-04-04     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  20120163     Citation Subset:  AIM; IM    
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MeSH Terms
Cartilage, Articular / anatomy & histology*,  chemistry,  physiology
Chondroitin Sulfates / chemistry
Contrast Media / diagnostic use
Gadolinium DTPA / diagnostic use
Ligaments / anatomy & histology
Magnetic Resonance Imaging / methods*
Osteoarthritis / pathology
Patella / physiology
Sodium / metabolism
Tendons / anatomy & histology
Grant Support
WT 088908/Z/09/Z//Wellcome Trust
Reg. No./Substance:
0/Contrast Media; 9007-28-7/Chondroitin Sulfates; 9NEZ333N27/Sodium; K2I13DR72L/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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